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________ is composed of multiple globular molecules polymerized to form long chains or filaments.


A) Actin
B) Tropomyosin
C) Troponin
D) Myosin
E) Titin

F) A) and C)
G) B) and E)

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The tension generated in a skeletal muscle fiber is directly proportional to the number of


A) thick and thin filaments present.
B) nebulin and titin molecules present.
C) high-energy crossbridges formed.
D) low-energy crossbridges formed.
E) active sarcomeres.

F) All of the above
G) D) and E)

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Which of the following would cause the crossbridge to transition from a high force state to a low force state?


A) increasing myosin ATPase activity
B) increasing intracellular calcium
C) decreasing intracellular calcium
D) energizing the myosin head
E) decreasing myosin ATPase activity

F) All of the above
G) D) and E)

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Smooth muscle cells of blood vessels are described as integrating centers.Outline the various inputs that affect smooth muscle cells and how those are integrated.

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Myogenic responses, autonomic neurotrans...

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Which of the following statements is NOT correct regarding the motor units and their activation?


A) A motor unit in muscles of gross movement can have thousands of muscle cells.
B) All muscle fibers in a single motor unit are of the same fiber type.
C) A weak contractile stimulus activates fast-twitch motor units.
D) The metabolic capacity of muscle fibers within a motor unit can be altered.
E) At its peak intensity, a contractile stimulus will activate muscle fibers that are easily fatigued.

F) A) and D)
G) A) and C)

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The H zone contains


A) thick filaments.
B) thin filaments only.
C) actin only.
D) thick and thin filaments.

E) All of the above
F) B) and C)

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A contraction that generates enough force to move a load is known as ________, whereas one that generates force that equals the load is known as ________.


A) isotropic, isometric
B) isometric, eccentric
C) isotonic, isometric
D) isometric, isotonic
E) isotonic, eccentric

F) C) and D)
G) B) and E)

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For antagonistic muscle groups to move a limb, flexor contraction occurs coincident with


A) contraction of the extensor.
B) relaxation of the extensor.
C) no changes in the extensor.
D) contraction of the tendon.

E) B) and D)
F) C) and D)

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Myasthenia gravis is a disease characterized by reduction in the number of acetylcholine receptors on skeletal muscles.Which physiological process would be affected? What would someone afflicted by this disease experience? How may this disease be treated?

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Neuromuscular transmission would be affe...

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The force generated by a single muscle fiber can be increased by


A) increasing frequency of action potentials only.
B) increasing muscle length beyond optimal only.
C) increasing the asynchrony of recruitment only.
D) increasing frequency of action potentials and increasing muscle length beyond optimal only.

E) All of the above
F) C) and D)

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Put these events in the correct chronological sequence: 1) End-plate potentials trigger action potentials. 2) Transverse tubules convey potentials into the interior of the cell. 3) Acetylcholine binds to receptors on the motor end plate. 4) Ca²⁺ is released from the sarcoplasmic reticulum.


A) 1, 2, 3, 4
B) 3, 1, 2, 4
C) 2, 1, 4, 3
D) 3, 1, 4, 2
E) 4, 3, 2, 1

F) B) and C)
G) C) and D)

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The hydrolysis of ATP causes myosin to immediately


A) swivel, moving the actin molecule.
B) release ADP.
C) release from the actin.
D) rotate into a position (cocked) to bind to actin.
E) bind more tightly to the actin (rigor) .

F) A) and D)
G) A) and B)

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Smooth muscle fibers can sustain a contraction without fatigue by allowing dephosphorylated myosin to remain attached to actin in what is called the ________.

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A flexor is a skeletal muscle whose shortening moves attached bones


A) away from one another.
B) towards one another.
C) medially.
D) laterally.

E) None of the above
F) All of the above

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________ is the backup energy molecule that can be rapidly converted to ATP in active skeletal muscle.


A) Protein
B) Glucose
C) Fatty acid
D) Phosphocreatine

E) B) and D)
F) B) and C)

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The molecular event that occurs immediately after the power stroke is the


A) release of actin from the myosin head.
B) hydrolysis of ATP by the myosin head.
C) release of ADP from the myosin.
D) binding of tropomyosin to the myosin.
E) binding of actin to the myosin.

F) C) and E)
G) A) and E)

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The reductions in muscle force generation at lengths different from optimal are a result of a(n)________.

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decrease i...

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Match from the following list. -The band with the most overlap between thick and thin filaments, which unevenly scatters light leading to its' dark appearance.


A) A band
B) I band
C) Z disk
D) H zone
E) M line

F) D) and E)
G) None of the above

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Match the structures with the accurate description. -inward extensions of the muscle cell membrane


A) muscle fiber
B) fascicle
C) sarcolemma
D) myofibril
E) t-tubules

F) A) and D)
G) B) and E)

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This protein is activated by the Ca²⁺-calmodulin complex to phosphorylate the myosin light chain protein.


A) tropomyosin
B) myosin heavy chain
C) myosin light chain kinase
D) myosin light chain phosphatase

E) B) and C)
F) None of the above

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